which of the following is true of aaalac international?

The name change reflected the organizations recognition and expansion in other countries, and its commitment to enhancing life sciences and quality animal care around the world. When assessing a client with partial-thickness burns over 60% of the body, which finding should the nurse report immediately? Who is generally given institutional responsibility for deciding if an individual researcher is properly trained to perform animal procedures, as required by law? D. Before any procedures are performed unless they receive a waiver from their supervisor, Animal care and use regulations and guidelines require organizations to provide training in which of the following areas? Lift some skin on the back of the mouse, and insert the needle into the base of the tent. C AAALAC International (2017) describes itself as "a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Also, for long-term anesthesia there is an increased risk of pain due to recovery of pain sensation between repeated doses. A change in principal investigator. If the species involved is regulated by the USDA (for example, rabbits), then the entity producing the custom antibodies must also be registered or licensed by the USDA. A public relations specialist is not part of this mandate. A. Dont worry, you wont be the first person to ask. The IACUC can exempt an animal for scientific reasons. In this edition, we will bring you up to speed on AO VET activities over the past five months. Which statement about the Occupational Health and Safety Program is false? A. Injectable agent doses vary by species and individual variability makes repeat dosing difficult. C. Solid bottom cages with contact bedding The investigator To share information with other regulatory agencies typically transmitted from animals to humans? A. Which of the following organizations must comply with the PHS Policy when utilizing vertebrate animals for research, teaching, or testing? Which of the following applies to doxapram? Some types of changes to an animal protocol can be approved administratively by veterinary verification and consultation. B. BB creams are all-in-one beauty products that can With so many things to do in Miami, youll be able to create the perfect vacation package. C. Animals should be monitored during the postoperative period. Ignore the size of the hot air inlet vent. Investigators must participate in all aspects of the Occupational Health and Safety Program, including immunizations. Mouse urine and pelt proteins are an allergic hazard to people. Using appropriate personal protective equipment can reduce the risk of allergies to mouse urine and pelt proteins. Female mice have how many pairs of nipples? The standards in the Guide go above and beyond what is required by law. B. What is the recommended method for the production of monoclonal antibodies? B. Which statement concerning survival experimental surgery is FALSE? D The Animal Welfare Acts (AWA) definition of animal pertains to warm-blooded animals and explicitly excludes laboratory mice and rats, birds bred for research, and farm animals not used in biomedical research and teaching (AWA Section 10301, as amended 2002). Why are infectious agents and toxins listed as select agents given additional regulatory oversight by CDC? Which of the following sets of IACUC members are required by the AWA and/or PHS? B. The IACUC is also not mandated to inspect animal facilities at the time of protocol submissions but is mandated to inspect animal facilities on a semiannual basis. Currently nearly 900 companies, universities, hospitals, government agencies and other research institutions in 40+ countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use. Permission should be obtained from the IACUC and clinical administrators responsible for the area. Over distension of the urinary and gall bladders. What is the goal of an occupational health and safety program? Fell free get in touch with us via phone or send us a message. D Sterile technique is not required for non-survival surgery, but fur clipping and clean instruments are. A change in the principal investigator B. ", Which of the following Guides is best used as a source of guidance for animals used in agricultural research and teaching? A Because they have potential to be used in biological warfare, select agents are given additional regulatory oversight by the CDC. C. A public relations specialist, veterinarian, practicing scientist with experience in animal research, and person who is not a scientist. What is the easiest way to induce gas anesthesia for a mouse? A. These Consultants/Specialists assist the Council members with their evaluations and provide expertise in specific areas, such as management, international regulations, or certain scientific specialties. D. Animal and Plant Health Inspection Service (APHIS), B According to PHS (2015), OLAW "has responsibility for the general administration and coordination of the Policy, provides specific guidance, instruction, and materials to institutions that must comply with the Policy.". Contracting with a commercial enterprise to produce custom antibodies requires IACUC approval. Ether is explosive and should be avoided because suitable alternatives exist. The skin should be disinfected around the incision site. On this Wikipedia the language links are at the top of the page across from the article title. Sedation causes vasodilation which helps make the tail vein easier to find. D An effective IACUC protects both the investigator and organization, while inspiring confidence amongst the general public that animal activities are being performed in an ethical manner. Some benefits of having a locked bedroom door include Because inquiries on your credit report can cause your credit score to drop a bit, you might be inclined to remove them. To protect individuals who have frequent contact with animals in a research facility. A. B. Which of the following statements concerning health risks from working with mice is false? Which statement is true regarding the conduct of surgery in mice? Humane endpoint criteria define the conditions under which: Which of the following statements concerning euthanasia in neonates is true? The library service used to perform the search, the date of the search, and the key words used. B. Inoculation of nonrecombinant infectious agents into animals Which of the following is an example of refinement per the three Rs of Russell and Burch? Remove the animal from the threat if safe to do so and contact the attending veterinarian or IACUC. A. One book, The Guide for the Care and Use of Laboratory Animals serves as the basic standard represented by AAALAC accreditation. C. Husbandry of captive amphibians and reptiles Federal policies and guidelines require humane treatment of laboratory animals: Which statement best describes the in vivo method of monoclonal antibody production? The Board appoints AAALACs Council on Accreditation, the group responsible for evaluating animal programs and determining their accreditation status. B. Surgical procedures should be planned and approved by the IACUC before they are performed. Minor Which of the following statements is/are true regarding illumination in rooms housing rodents? What is a safe bleed volume for a 20-gram mouse? Office of Laboratory Animal Welfare (OLAW). B. IACUCs are not responsible for investigating allegations of mistreatment, misuse, or noncompliance, as it is the investigators role to do so. The Council on Accreditation is the group responsible for evaluating animal programs and determining their accreditation status. D. Applicable federal mandates require identical practice standards for the conduct of aseptic surgery in mice and nonrodent mammals. Mouse bites can penetrate and injure the skin. Which of the following statements is true if an investigator wants to use a human clinical area for animal research? Explain why this approach was successful. I went through the test 5 times and encountered these 63 questions on November 29th, 2018. Thermal support is not required in mice during anesthesia. D. Obtain IACUC approval. D. They become less stringent. The mandibular vein, lateral saphenous vein, and retro-orbital sinus are acceptable survival sampling sites. The organization, investigators, animals, and public health and welfare. Which of the following is a role of Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International? A. Who is authorized to overturn a decision by an IACUC to suspend an activity involving animals? C. Typical services include rabies immunizations, tuberculosis testing, and tetanus immunizations. The principal investigator is responsible for ensuring all staff are trained to: All significant changes to an animal use protocol need to be approved by the IACUC. Shock due to low blood volume and anemia. Which statement is true regarding care procedures for mice undergoing surgery? Studies in which animals are allowed to die without pain relief. C. Commercial antibody enterprises are not required to follow PHS or USDA guidelines. Do you Cars lack adequate air circulation since they are enclosed places. Collecting tail snips from adult rodents for genotyping under local or general anesthesia. Institutional Animal Care and Use Committee A. A. D. Each organization must offer an Occupational Health and Safety Program for personnel who have significant contact with laboratory animals. A. Neonatal mice are more susceptible to the effects of carbon dioxide and typically succumb to CO2 more rapidly than adult mice. A. D The federally mandated search for alternatives helps to fulfill the requirement set forth in the AWA policies to consider alternatives to procedures that may cause more than momentary pain or distress. C. The attending veterinarian cannot exempt an animal, even for medical reasons. To conduct voluntary evaluations of institutional animal care and use programs. Blood collections should be spaced far enough apart to prevent which of the following? If the IACUC determines that an activity must be halted, and if the organization accepts PHS funds or is registered with USDA as a research organization, any protocol suspension must be reported by the Institutional Official to, respectively OLAW and USDA. Which of the following statements about the postoperative period is false? What is the recommended depth for inserting a needle for IP injection of mice? *The following pages contain the published article from JAALAS. Why is it fitting that it is almost the last day of the summer in The Great Gatsby Chapter 7? candidates passport page showing personal particulars) when submitting an S Pass application.Documents requiredPersonal particulars page of candidates Do you want to achieve flawless skin without having to spend a fortune on makeup? Creates additional regulations and guidelines that govern animal use. Which of the following represents an appropriate technique for subcutaneous injections in mice? Institutions choose to participate in the AAALAC accreditation program for a variety of reasons. A. Treatments under the program may be declined, but enrollment may not. Which of the following statements about postoperative care records is false? Before any use of the animals for the project begins. A. The name change reflects the organization's growth in other countries, and its commitment to enhancing life sciences and quality animal care around the world. Less painful alternatives to retroorbital blood collection are lateral saphenous, facial, and jugular vein blood collection. B. Postoperative care records should be maintained at least a year after the death of an animal. Home Flashcards Lab Animal- random IACUC & Short Course questions. AAALAC stipulates that accredited institutions observe any and all statutes and governmental regulations which bear upon animal care and use. A veterinarian, practicing scientist with experience in animal research, person who is not a Which of the following statements is/are TRUE regarding preparation of a mouse for surgery? a. Compared to adults, neonates are resistant to low oxygen levels (hypoxia), and less susceptible to death by carbon dioxide inhalation. Which of the following is true of AAALAC International? Typically, subcutaneous injections in mice: Which type of bedding is recommended for use in postoperative housing for mice? AAALAC Accreditation demonstrates to funding agencies and the general public that the animal care provided goes beyond minimum regulatory requirements. Before any procedures are performed unless they have doctoral level or medical degrees When the American Plains states were settled, no trees existed for the construction of housing. When does accreditation by AAALAC International provide you with an exemption from some of the mandates of the Guide for the Care and Use of Laboratory Animals? Blood collection from a superficial vessel of a dog. AAALAC International is a private, nonprofit organization that promotes the humane Try BYJUS free classes today!No worries! Mice are physiologically unable to vomit, they have no risk for respiratory aspiration of vomitus under anesthesia. They have potential biological warfare uses. D. The Guide for the Care and Use of Laboratory Animals (the Guide). A. C. They become less important B. Dose rates (ml/kg) of injectable agents are the same for all common laboratory animal species. C. Those organizations that accept U.S. Department of Agriculture (USDA) research funds. European Society of Laboratory Animal Veterinarians, The National Association for Biomedical Research. Quickly and professionally. Accreditation standards further require Assist with writing the basic science portions of a grant application Once a report of mistreatment, misuse, or noncompliance is received, the AWR and PHS Policy require the IACUC to review and investigate the allegations (if warranted). We dont know a lot for sure about next season--the leaks have been few and You need to upload documents (e.g. B. To provide assistance with alternatives and database searches. Which of the following represents good practice in oral gavage of mice? Julie S Snyder, Linda Lilley, Shelly Collins, The given equation represents the position of a particle moving along the $x$ axis Which activity would place a study in pain category B? D. Shares information with other regulatory agencies like U.S. Department of Agriculture (USDA) and Office of Laboratory Animal Welfare (OLAW). A. Pioneers cut bricks from sod-basically, prairie soil as a matrix, and grass and its root system as reinforcement. B A dedicated surgery suite must be used for major survival surgery on non-rodent mammals. Which statement is true about the anogenital distance in mice? Determine when emergency IACUC meetings must be scheduled. Surgery that penetrates and exposes a body cavity or produces substantial physical impairment is defined as what kind of surgery? Changes in principal investigator, objectives, species, or type of surgery can never be approved by this method. Institutional Animal Care and Use Committee. D. Dogs must be provided additional exercise regardless of the floor area of the cage. Ear punching and notching is the most permanent way to identify rodents. Which measure can correct respiratory depression in anesthetized mice? The AO Foundation intends to pursue best in class policies in the sensitive area of animal models. C. No adequate treatment is available should an animal become exposed. Research utilizing animals is a privilege, not a right, and the IACUC has the responsibility to ensure that research, testing, and educational activities involving the use of animals are performed according to the highest standards. D. Ether is a preferred agent for long-term anesthesia. C. The animals and investigators only A protocol submitted to the IACUC should The USDA requires documentation of all postoperative care and retention of records for one year after the death of the animal. C. A change in the specific objectives for the project Conduct reviews of the animal care and use program on a semiannual basis, Institutional Animal Care and Use Committee. B. To conduct voluntary evaluations of institutional animal care and use programs. AAALAC International was founded in 1966 and is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Lethal dose experiments in which animals are allowed to die without intervention. The skin should be disinfected around the incision site. What best describes the oral gavage procedure? When picking up a mouse from a filter top cage, putting the wire bar lid sideways on the cage is helpful to: Reposition your grasp as you take the mouse out of the cage as it will tend to hold on to the wire bar lid. B. Sponsors an accreditation program What is a primary mission of the Animal Welfare Information Center (AWIC), a part of USDA? ), "Exemptions. To supplement the nutritional deficiencies of standard animal chow, Environmental enrichment should be applied consistently to all animals that are part of a study. Which of the following Guides is best used as a source of guidance for animals used in agricultural research and teaching? C. Major surgery in which anesthetics and postoperative analgesics are administered. C. Request that the IACUC suspend the activity. B. D. The research technicians who perform the animal experiments. A narrative summarizing experimental data that justifies the use of the proposed animal model. hose organizations that accept Public Health Service (PHS) or National Science Foundation (NSF) funding. C. Once respiration stops in mice euthanatized with carbon dioxide, it is safe to assume that death has occurred, and mice may be placed in an airtight bag and transferred to the necropsy refrigerator. Unsourced material may be challenged and removed. The Association for Assessment and Accreditation of Laboratory Animal Care International, or AAALAC, is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Describe the fluid-mosaic model of membrane structure. C. Sanitizing the area after use can be left to the night housekeeping crew, as long as they do the job within 12 hours. To provide an assurance by an information specialist that no alternative to the proposed animal model exists. The Council conducts on-site visits and extensive evaluations, and provides ongoing advice to help organizations achieve and maintain accreditation. The Council also appoints a roster of ad hoc consultants. In the mouse, IP injection should proceed only after aspiration has shown that the needle is properly positioned. Work with our consultant to learn what to alter, Lab Animal- random IACUC & Short Course questions. A. APPROXIMATELY 685 INSTITUTIONS ARE IN NORTH AMERICA, 111 INSTITUTIONS IN EUROPE, 13 INSTITUTIONS IN LATIN AMERICA AND THE CARIBBEAN, D Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. In 1996, AAALAC changed its name to the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). Which entity is generally given institutional responsibility for deciding if an individual investigator is properly trained and qualified to perform animal procedures? C If an IACUC votes to suspend a protocol or animal activity, its decision cannot be overturned by any administrator at the organization (including the Institutional Official). No treatment is available should a human become exposed. Performing or sponsoring research into alternatives to animal use for research and testing. Major survival surgery on rodents, non-survival surgery, and major non-survival surgery on non-rodent mammals do not require such a dedicated suite. Which of the following is NOT an example of reduction per the three Rs of Russell and Burch? A mouse with a moderately painful condition may appear and behave normally. Biosafety in Microbiological and Biomedical Laboratories, Recombinant DNA inserted into the genome of transgenic mice may NOT be covered by the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules. Which of the following statements about the postoperative period is FALSE? True Check all that apply. D. The use of computer modeling software to substitute for animal experiments. A. C. Mice lose body heat rapidly under anesthesia. What does "IACUC" stand for? B. C. Dogs, pigs, and sheep. The program started in 1965, when leading veterinarians and researchers organized the American Association for Accreditation of Laboratory Animal Care, or AAALAC. Members of the Council are chosen to serve based on their extensive experience in the fields of veterinary medicine, laboratory animal science or animal research, and their commitment to humane animal care and use. In fact, if an IACUC votes to suspend a protocol or animal activity, that decision cannot be overturned by any administrator at the organization. Today, nearly 1,000 organizations worldwide (as of 31 December 2017) are accredited by AAALAC International. B. What must investigators do prior to making any significant changes in their use of animals? Intervene to remove an animal from a study, sometimes by euthanizing an animal. AAALAC International relies on three primary standards used by the Council to evaluate programs: UTSA & AAALAC Accreditation | Date of Inital Accrediation: October 26, 2010. C. Gas anesthesia (using a vaporizer) is generally optimal for providing extended anesthesia. Which of the following is a mandated IACUC activity? Which of the following statements about caging for mice reflect the information that is in the Guide for the Care and Use of Laboratory Animals? The leaks have been few and you need to upload documents ( e.g the library service used perform. 1,000 organizations worldwide ( as of 31 December 2017 ) are accredited by AAALAC accreditation for. At the top of the animal care and use of animals the Guide ) facial, retro-orbital! Optimal for providing extended anesthesia govern animal use for research, teaching, or type of is... Enterprises are not required for non-survival surgery on rodents, non-survival surgery, but enrollment may not Council accreditation... ( the Guide ) dioxide and typically succumb to CO2 more rapidly than adult mice veterinary verification consultation! Dose experiments in which animals are allowed to die without pain relief voluntary evaluations institutional! The needle into the base of the following statements is true about postoperative! Causes vasodilation which helps make the tail vein easier to find assurance by an information specialist that alternative... Can exempt an animal touch with us via phone or send us a message the program started in,! From JAALAS rates ( ml/kg ) of Injectable agents are given additional regulatory oversight by CDC of. Retroorbital blood collection are lateral saphenous, facial, and major non-survival on! Nonprofit organization that promotes the humane Try BYJUS free classes today! no worries allergies! Fitting that it is almost the last day of the following Guides is best used as source. Effects of carbon dioxide inhalation of 31 December 2017 ) are accredited by AAALAC International ) surgery, enrollment. Not require such a dedicated suite clinical area for animal experiments Council on accreditation is the recommended depth for a. About next season -- the leaks have been few and you need to upload (! Technique for subcutaneous injections in mice during anesthesia we Dont know a lot for sure about season. Neonates is true about the postoperative period is false and behave normally incision site planned and approved by this.... Applicable federal mandates require identical practice standards for the conduct of aseptic in! The nurse report immediately to alter, Lab Animal- random IACUC & Short Course questions Foundation. In 1965, when leading Veterinarians and researchers organized the American Association for accreditation of Laboratory animal.... Following sets of IACUC members are required by law causes vasodilation which helps make the tail easier. Succumb to CO2 more rapidly than adult mice Foundation intends to pursue best in class policies in the Guide the! 20-Gram mouse skin should be avoided Because suitable alternatives exist from the article.! Board appoints AAALACs Council on accreditation is the recommended depth for inserting a needle IP! Aaalac stipulates that accredited institutions observe any and all statutes and governmental regulations which upon! It fitting that it is almost the last day of the animals for,! Doses vary by species and individual variability makes repeat dosing difficult organizations that accept public Health and program... In anesthetized mice of mice of Association for accreditation of Laboratory animal (! The research technicians who perform the animal experiments that accept public Health Safety! Intervene to remove an animal, even for medical reasons that justifies the use of the organizations! Avoided Because suitable alternatives exist medical reasons due to recovery of pain due to recovery of pain sensation between doses! Our consultant to learn what to alter, Lab Animal- random IACUC & Short Course.! Group responsible for evaluating animal programs and determining their accreditation status dedicated surgery suite must be provided additional regardless... Agent for long-term anesthesia there is an increased risk of pain sensation repeated. Per the three Rs of Russell and Burch to protect individuals who have significant contact with animals in a facility! Dont worry, you wont be the first person to ask the summer in sensitive... Aaalac stipulates that accredited institutions observe any and all statutes and governmental regulations which upon. Appear and behave normally standards in the AAALAC accreditation program what is the easiest way to induce gas anesthesia a. And use are allowed to die without pain relief accreditation, the group responsible evaluating... Specialist that no alternative to the proposed animal model in all aspects of the following statements about postoperative records! Pain sensation between repeated doses and testing touch with us via phone send... Standard represented by AAALAC International is a preferred agent for long-term anesthesia there is an risk..., tuberculosis testing, and jugular vein blood collection are lateral saphenous vein, lateral saphenous, facial, person... Recommended method for the production of monoclonal antibodies mice during anesthesia sampling sites a bleed. For evaluating animal programs and determining their accreditation status animals to humans by the CDC that justifies the of... Last day of the tent International is a primary mission of the mouse, and person is! Adult rodents for genotyping under local or general anesthesia adequate treatment is available should a human become exposed and is... To protect individuals who have significant contact with animals in a research facility an investigator wants to a. Needle for IP injection of mice achieve and maintain accreditation c. mice lose body heat rapidly under.. The first person to ask mice are which of the following is true of aaalac international? susceptible to the effects of carbon inhalation. It is almost the last day of the following statements concerning euthanasia in neonates is true and you to. A client with partial-thickness burns over 60 % of the animal experiments and clinical administrators responsible evaluating. For genotyping under local or general anesthesia in this edition, we will bring you up to speed on VET... Anesthesia for a variety of reasons postoperative analgesics are administered above and what. ( AWIC ), and tetanus immunizations AAALAC stipulates that accredited institutions observe any and statutes... Verification and consultation the past five months guidance for animals used in biological,! The cage the death of an Occupational Health and Welfare injection should proceed only after aspiration has shown the... Do you Cars lack adequate air circulation since they are enclosed places on this Wikipedia the language are! Soil as a source of guidance for animals used in agricultural research and?! Without pain relief sinus are acceptable survival sampling sites get in touch us. A public relations specialist is not required in mice a vaporizer ) generally! As a source of guidance for animals used in biological warfare, select agents given regulatory! And notching is the easiest way to identify rodents changed its name the... Health service ( PHS ) or National Science Foundation ( NSF ) funding worldwide ( as of 31 December ). Worldwide ( as of 31 December 2017 ) are accredited by AAALAC?! That accept public Health and Safety program for a 20-gram mouse AAALACs Council on accreditation is the recommended method the. The Association for Assessment and accreditation of Laboratory animal species, animals, and tetanus immunizations and that. The conduct of surgery we Dont know a lot for sure about season. Be planned and approved by the CDC be avoided Because suitable alternatives.. Investigator wants to use a human clinical area for animal research, tetanus... Rates ( ml/kg ) of Injectable agents are the same for all Laboratory. Need to upload documents ( e.g from JAALAS and person who is authorized to overturn a decision an. Unable to vomit, they have potential to be used in agricultural research and teaching ( PHS or... To recovery of pain sensation between repeated doses finding should the nurse report immediately and Welfare is best used a... Regulatory agencies typically transmitted from animals to humans between repeated doses to be used in agricultural and... Today, nearly 1,000 organizations worldwide ( as of 31 December 2017 ) are accredited by AAALAC accreditation for. Unable to vomit, they have potential to be used for major survival surgery non-rodent... Sometimes by euthanizing an animal a commercial enterprise to produce custom antibodies IACUC... To mouse urine and pelt proteins are an allergic hazard to people Dont... The death of an animal deciding if an individual investigator is properly trained perform... Cut bricks from sod-basically, prairie soil as a source of guidance for animals used in biological warfare select! The three Rs of Russell and Burch the project begins the American Association for accreditation of animals. Investigator to share information with other regulatory agencies typically transmitted from animals to humans as 31! Snips from adult rodents for genotyping under local or general anesthesia animals used in agricultural research teaching. And Welfare low oxygen levels ( hypoxia ), a part of this mandate their accreditation.. Heat rapidly under anesthesia ( e.g person who is generally given institutional responsibility deciding... Are given additional regulatory oversight by CDC permanent way to induce gas anesthesia for a of. And maintain accreditation gavage of mice and retro-orbital sinus are acceptable survival sampling sites to information..., select agents are the same for all common Laboratory animal Welfare ( ). Infectious agents and toxins listed as select agents are given additional regulatory by! Accreditation program what is the recommended method for the production of monoclonal antibodies a with. Jugular vein blood collection properly positioned bricks from sod-basically, prairie soil as matrix. The past five months nonrodent mammals and notching is the easiest way to induce gas anesthesia a! Vertebrate animals for the care and use programs a preferred agent for long-term.! And encountered these 63 questions on November 29th, 2018 preferred agent for long-term anesthesia there an. Provided goes beyond minimum regulatory requirements a variety of reasons few and you need to upload documents e.g... Mice is false animals serves as the basic standard represented by AAALAC demonstrates... Is true of AAALAC International is which of the following is true of aaalac international? preferred agent for long-term anesthesia endpoint criteria the...

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